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KMID : 0644120210340040030
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Journal of Oriental Gynecology
2021 Volume.34 No. 4 p.30 ~ p.45
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The Effects of Pregnancy-Related Water Extract of 3 Types Herbal Medicines and Ethanol Extract of Moutan Radicis Cortex on the Endometrial and Placental Cells
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Park Seo-Ye
Noh Eui-Jeong
Seo Chang-Seob
Lee Sung-Ki
Shin Hyeun-Kyoo
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Abstract
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Objectives: This study was performed to investigate the effects of pregnancy-related four herbal medicines (Samul-tang, Onkyung-tang, Chokyungjongok-tang and Moutan Radicis Cortex) on the endometrial and placental cells.
Methods: In this study, we examined viability and decidualization of telomerase immortalized human endometrial stromal cell lines (T-HESCs) and viability and invasion ability of human first trimester trophoblast cell lines Sw.71 by four herbal medicines (Samul-tang, Onkyung-tang, Chokyungjongok-tang and Moutan Radicis Cortex)
Results: In the study, we showed that Samul-tang, Onkyung-tang, Chokyungjongok-tang increased decidualization marker prolactin (PRL) and insulin-like growth factor-binding protein 1 (IGFBP1) in T-HESCs. Moutan Radicis Cortex decreased the mRNA level of PRL and IGFBP1, and the protein level of PRL and IGFBP1 had no significant effect. Moreover, four herbal medicines reduced invasion ability of Sw.71 cells.
Conclusions: These results suggest that Samul-tang, Onkyung-tang, and Chokyungjongok -tang have beneficial effects on successful embryo implantation and pregnancy maintenance by increasing decidualization markers such as PRL and IGFBP1. Moutan Radicis Cortex reduces the mRNA levels of PRL and IGFBP1, which may adversely affect pregnancy. Further investigations are needed to elucidate the significance of the decreased invasive ability of Sw.71 cells induced by four herbal medications.
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KEYWORD
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Endometrial Stromal Cell, Decidualization, Trophoblast, Invasion, Herbal Medicines, Samul-tang, Onkyung-tang, Chokyungjongok-tang, Moutan Radicis Cortex
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